Kajima's Integrated Engineering Services for Pharmaceutical-related Facilities

Kajima will help create the optimum facilities.

Kajima's services include all phases of engineering to plan, survey, design, build and maintain R & D / production facilities and distribution centers.

Kajima will assist our clients by providing specific technologies, system engineering and general coordination services required for pharmaceutical facility projects:

	Production System Engineering
	Validation Engineering
	Environmental Engineering
	Utility Engineering
	Architectural Engineering
	Overseas Support

Kajima will support our clients at every stage of projects with our technologies based on plenty of experience and performance.

Survey/Planning --> Basic Plan --> Design/Engineering --> Procurement -->

Construction --> Test Run/Adjustment --> Customer Support/Repair & Maintenance

Kajima will perform the optimum validation engineering on a phase-to-phase basis.

Step 1: For Master plan and Design
Kajima will prepare the most appropriate documents on the coordination with clients' requirements and Kajima's standard specifications such as VMP, DQ protocol, DQ checklists, etc.

Step 2: For Implementation
Kajima will select the specifications appropriate for facilities from its validation system which has been already established according to various dosage forms, preparation equipments and process, and then prepares and implements IQ and OQ documents. (Computer validation is also available to PQ.)

Step 3: For Documentation
Kajima will assist to build the standard form for validation documents such as header, footer, document numbering system, definitions of words etc. Kajima will also compile and present validation-related documents, including their record of changes and revisions, in a comprehensive form. Kajima will also prepare summary reports.

Kajima will offer a wide range of environmental engineering services for pharmaceutical facilities.

	Environmental Symbiosis
	Zero Emission
	ISO 14000s
	Treatment/Recycle of Wastes
	Measures for Contaminated Soil and Water
	Measures for Noise and Vibration
	Measures for Air, Water and Energy
	Assessment, Greening and Protection of Natural Environment

Water provision is vital to pharmaceutical facilities. In view of this Kajima will fulfill integrated engineering services including water and waste water treatment.

Block Flaw for water and drainage systems:
Kajima will offer integrated engineering service from A to Z in factory process.

Case study 1:	Bottle washer system Kajima will offer aquatic engineering service for production machinery.
Case study 2:	CIP detergent drain system and data on water quality. Kajima will offer aquatic engineering service necessary for the process.

Kajima will support functionality, safety and future of architectural structures with its state-of-the- art technologies.

Flexible building & equipment integrated system
Structural response control, quake-proof and quake-absorbing technologies that assure safety of facilities
Renewal engineering that improves functionality, safety and amenity
Lifecycle engineering that supports property and facilities in general from clients' point of view

Kajima's Pharmaceutical Project Experience

Here are Kajima's credentials, who is well versed in pharmaceutical product engineering from laboratory to delivery center.

STAGE		TYPE OF FACILITY
1. New Drugs Development Stage :		Research Laboratory
2. Pre-clinical Testing Stage :		Development Laboratory New Medicine Laboratory Preparation Laboratory Animal Experimental Facility RI Experimental Facility Bio-related Facility Cosmetics Laboratory
3. Clinical Testing Stage :		Curative Medicine Production Facility
4. Production Stage :		Original Medicine Production Facility Aseptic Medicine Production Facility Solid Medicine Production Facility Liquid Medicine Production Facility Herbal Medicine Production Facility
5. Distribution Stage :		Medication Logistics Facility

MAJOR CLIENTS:

Foreign:
Pfizer Pharmaceutical Co., Ltd.; Nippon Medi-physics Co., Ltd.; Hoechst Akitiengesellschaft; Up John; Dupon Japan Ltd.; Abott Laboratories; Three-M Pharmaceutical Co., Ltd.; Yansen Kyowa Co., Ltd.; Alpha Therapeutic Manufacturing; PMP Fermentation, Inc.; Nippon Sintex Co., Ltd., etc

Japanese:
Takeda Chemical Industries, Ltd.; Eisai Co., Ltd.; Kaken Pharmaceutical Co., Ltd.; Hisamitsu Pharmaceutical Co., Ltd.; Kanegafuchi Chemical Ind. Co., Ltd.; Kobayashi Pharmaceutical Co., Ltd.; Institute of Physical and Chemical Research; Chugai Pharmaceutical Co., Ltd.; Taisho Pharmaceutical Co., Ltd.; Snow Brand Milk Products, Co., Ltd.; Fuji Pharmaceutical Co., Ltd.; Taiho Pharmaceutical Co., Ltd.; Otsuka Pharmaceutical Co., Ltd.; Kyowa Hakko Kogyo Co., Ltd.; Teijin Limited; Fujisawa Pharmaceutical Co., Ltd.; Yamanouchi Pharmaceutical Co., Ltd.; Sumitomo Pharmaceutical Co., Ltd.; Japan Red Cross Society; Sato Pharmaceutical Co., Ltd; Nissui Pharmaceutical Co., Ltd.; Towa Pharmaceutical Co., Ltd.; Kissei Pharmaceutical Co., Ltd.; Taiyo Pharmaceutical Co., Ltd.; Tsumura & Co.; Teikoku Pharmaceutical Co., Ltd.; Daiichi Pharmaceutical Co., Ltd.; Torii Pharmaceutical Co., Ltd.; Benten Pharmaceutical Co., Ltd.; Chemical Blood Research Foundation; Uchida Herbal Medicine Co., Ltd.; Toagosei Chemical Industry Co., Ltd.; Santen Pharmaceutical Co., Ltd.; Yoshindo Co., Ltd., etc